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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-BC1464
BC1464

Chemical Structure : BC1464

CAS No.:

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BC1464 (BC 1464)

货号: PC-20317Not For Human Use, Lab Use Only.

BC1464 (BC 1464) is a small molecule inhibitor of ubiquitin E3 ligase receptor component FBXO7, efficiently decreases the interaction between FBXO7 and PINK1, increases cellular PINK1 concentrations and activities.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BC1464 (BC 1464) is a small molecule inhibitor of ubiquitin E3 ligase receptor component FBXO7, efficiently decreases the interaction between FBXO7 and PINK1, increases cellular PINK1 concentrations and activities.
    BC1464 stabilized PINK1 and increased PINK1 protein levels in cells in a dose-dependent manner through inhibiting FBXO7.
    BC1464 (10 ng/mL) potently blocked LPS-stimulated release of the proinflammatory cytokine TNF-α in human PBMCs, also selectively increased PINK1 protein levels and inhibited proinflammatory TNF-α release in response to endotoxin in human lung explants.
    BC1464 (5 mg/kg, i.p.) significantly decreased lavage protein, cell numbers, cytokine levels, and tissue infiltrates with restoration of PINK1 levels in experimental mouse pneumonia.
    BC1464 stabilized PINK1 expression in the presence of CHX in neuronal cells with IC50 of 5.2 μg/mL.
    BC1464 significantly decreased MPP+-elicited injury in human SH-SY5Y cells, exhibited significant protection against Parkinsonian toxin 6-hydroxydopamine (6-OHDA) in fibroblasts from Parkinson's disease patients.

    物理化学性质&存储条件

    分子量 466.56
    分子式 C24H26N4O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    S-(4-oxo-3-(4-oxo-4-(phenylamino)butyl)-3,4-dihydroquinazolin-2-yl) ((tetrahydrofuran-2-yl)methyl)carbamothioate

    参考文献

    1. Yuan Liu, et al. JCI Insight. 2020 Jun 4;5(11):e131834.

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