BIO-2007817 | Parkin activator | Probechem Biochemicals

Chemical Structure : BIO-2007817

CAS No.:

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BIO-2007817 (BIO 2007817)

货号: PC-72861Not For Human Use, Lab Use Only.

BIO-2007817 is a small-molecule positive allosteric modulator of Parkin E3 ligase with EC50 of 0.17 uM (TR-FRET).

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2 mg	￥3580	In stock
5 mg	￥5580	In stock
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25 mg		Get quote

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生物&药学活性

BIO-2007817 is a small-molecule positive allosteric modulator of Parkin E3 ligase with EC50 of 0.17 uM (TR-FRET).
BIO-2007817 stimulated Parkin autoubiquitination as measured by Western blots in a concentration-dependent manner, was also able to induce the appearance of monoubiquitinated forms of Miro1.
BIO-2007817 induced the appearance of slower-migrating Parkin species in a concentration-dependent manner with maximal efficacy at 20 uM in Parkin autoubiquitination assay.
BIO-2007817 does not affect the rate of Parkin translocation to mitochondria nor the number of mitochondria within lysosomes.

物理化学性质&存储条件

分子量	552.679
分子式	C32H36N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-((R)-6-isopropyl-3-(4-(1,2,3,4-tetrahydroquinoline-1-carbonyl)phenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)-2-methoxy-2-(1-methyl-1H-pyrazol-4-yl)ethan-1-one

参考文献

1. Shlevkov E, et al. iScience. 2021 Dec 18;25(1):103650.
2. Sauvé V, et al. Nat Commun. 2024 Sep 19;15(1):7707.

BIO-2007817 (BIO 2007817)

生物&药学活性

物理化学性质&存储条件

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BIO-2007817 (BIO 2007817)

生物&药学活性

物理化学性质&存储条件

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