BC18813 | DCAF7 inhibitor | Probechem Biochemicals

Chemical Structure : BC18813

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BC18813 (BC 18813)

货号: PC-49194Not For Human Use, Lab Use Only.

BC18813 (BC 18813) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 48 nM in cell-based assays.

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生物&药学活性

BC18813 (BC 18813) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 48 nM in cell-based assays.
BC18813 decreases TFEB ubiquitination and significantly reduces the measured interaction between DCAF7 and TFEB in nucleus of cells.
BC18813 attenuates a wide range of viral infections including SARS-CoV-2 infection, prevents virally-triggered TFEB degradation and dose-dependently reduces OC43 coronavirus infection, reduces HCoV-OC43 NP expression with IC50 of 0.3 uM.

物理化学性质&存储条件

分子量	356.364
分子式	C20H13FN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(7-fluoro-1H-indol-5-yl)-2-(pyridin-4-yl)pyrido[2,3-d]pyrimidin-4-amine

参考文献

1. Yuan Liu, et al. Res Sq. 2021 Apr 23;rs.3.rs-419305.

BC18813 (BC 18813)

生物&药学活性

物理化学性质&存储条件

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BC18813 (BC 18813)

生物&药学活性

物理化学性质&存储条件

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