Chemical Structure : OICR-8268
货号: PC-20292Not For Human Use, Lab Use Only.
OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP).
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OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP).
OICR-8268 exhibits cellular target engagement with EC50 of 10 μM as measured by cellular thermal shift assay (CETSA).
OICR-8268 shows high affinity for binding to the DCAF1 WDR domain with ITC Kd of 278 nM.
OICR-8268 is a potent and in-cell active small molecule for the DCAF1 WDR domain.
DCAF1 is a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP), plays a critical physiological role in protein degradation, and is considered a drug target for various cancers.
分子量 | 439.24 | |
分子式 | C19H14Cl2F2N4O2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
1. Li ASM, et al. J Med Chem. 2023 Mar 22. doi: 10.1021/acs.jmedchem.2c02132.
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