PELI1-EGFR inhibitor S62

Chemical Structure : PELI1-EGFR inhibitor S62

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货号: PC-20113Not For Human Use, Lab Use Only.

PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between PELI1 and EGFR, suppresses breast cancer metastasis.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between Pellino-1 (PELI1) and EGFR, suppresses breast cancer metastasis.
PELI1-EGFR inhibitor S62 (5-10 uM) reduced both protein levels of PELI1 and EGFR in MDA-MB-231 cells, also decrease of the membrane EGFR.
PELI1-EGFR inhibitor S62 did not block the phosphorylation of EGFR upon EGF stimulation.
PELI1-EGFR inhibitor S62 reduced the tyrosine and threonine phosphorylation of PELI1 and K63-linked ubiquitination of EGFR.
PELI1-EGFR inhibitor S62 inhibited the metastasis of MDA-MB-231 cells MDA-MB-231 cells-derived tumor nodules in lung after caudal vein injection.
PELI1-EGFR inhibitor S62 is a disruptor of PELI1 and EGFR interaction but not binding to PELI1 or EGFR alone.
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins, EGFR is positively correlated with PELI1 expression in breast cancers.

物理化学性质&存储条件

分子量	412.59
分子式	C24H32N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-decanamidophenyl)thio)-N-methylbenzamide

参考文献

1. Qi J, et al. Oncogenesis. 2023 Feb 25;12(1):9.