| Cat. No. |
Product Name |
Information |
| PC-20292 |
OICR-8268
DCAF1 ligand
|
OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP). |
| PC-20113 |
PELI1-EGFR inhibitor S62
PELI1/EGFR inhibitor
|
PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between PELI1 and EGFR, suppresses breast cancer metastasis. |
| PC-49510 |
NAB2
Nedd4 inhibitor
|
NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM. |
| PC-49453 |
Thiolutin
HOIP inhibitor
|
Thiolutin (Acetopyrrothin) is a small molecule inhibitor of the catalytic activity of E3 ubiquitin ligase RING finger protein 31 (RNF31, also known as HOIP), a catalytic subunit of linear ubiquitin chain assembly complex (LUBAC). |
| PC-49196 |
BC18630 free base
DCAF7 inhibitor
|
BC18630 free base (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays. |
| PC-49194 |
BC18813
DCAF7 inhibitor
|
BC18813 (BC 18813) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 48 nM in cell-based assays. |
| PC-49193 |
BC18630
DCAF7 inhibitor
|
BC18630 (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays. |
| PC-38778 |
WSB1 inhibitor 4
WSB1 inhibitor 4
|
WSB1 inhibitor 4 is a small molecule inhibitor and degarder of the ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1), displays migration inhibitory activity against WSB1-overexpressing cells. |
| PC-38449 |
BC-1258
FBXO3 inhibitor, FBXL2 activator
|
BC-1258 is a specific small molecule FBXO3 inhibitor and F-box/LRR-repeat protein 2 (FBXL2) activator, BC-1258 is sufficient to stabilize and upregulate FBXL2 levels, selectively induces Aurora B degradation in vitro and in vivo. |
| PC-72861 |
BIO-2007817
Parkin activator
|
BIO-2007817 is a small-molecule positive allosteric modulator of Parkin E3 ligase with EC50 of 0.17 uM (TR-FRET). |
| PC-72549 |
CRL inhibitor 33-11
E3 CRL4 inhibitor
|
CRL inhibitor 33-11 is a small moelcule cullin-RING E3 ubiquitin ligase 4 (E3 CRL4) inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely. |
| PC-72548 |
KH-4-43
E3 CRL4 inhibitor
|
KH-4-43 is a small moelcule E3 CRL4 inhibitor and exhibits antitumor potential, directly and selectively binds to the purified E3 ROC1-CUL4A CTD complex with Kd of 83 nM. |
