CRL inhibitor 33-11 | E3 CRL4 inhibitor | Probechem Biochemicals

Chemical Structure : CRL inhibitor 33-11

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CRL inhibitor 33-11 (E3 CRL4 inhibitor)

货号: PC-72549Not For Human Use, Lab Use Only.

CRL inhibitor 33-11 is a small moelcule cullin-RING E3 ubiquitin ligase 4 (E3 CRL4) inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CRL inhibitor 33-11 is a small moelcule cullin-RING E3 ubiquitin ligase 4 (E3 CRL4) inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.
CRL inhibitor 33-11 binds to ROC1-CUL1 more effectively than ROC1-CUL1-Nedd8.
CRL inhibitor 33-11 showed the ability to inhibit ubiquitination by ROC1–CUL1 more potently than that by ROC1-CUL1-Nedd8.
CRL inhibitor 33-11 inhibited the ubiquitination of CK1α by CRL4CRBN in vitro.

物理化学性质&存储条件

分子量	388.302
分子式	C19H11F3N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7,8-dihydroxy-3-phenoxy-2-(trifluoromethyl)-4H-chromen-4-one

参考文献

1. Kenneth Wu, et al. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2007328118.