NAB2 | Nedd4 inhibitor | Probechem Biochemicals

Chemical Structure : NAB2

CAS No.: 1504588-00-4

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NAB2 (Nedd4 inhibitor NAB2)

货号: PC-49510Not For Human Use, Lab Use Only.

NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM.

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
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生物&药学活性

NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM.
NAB2 rescues α-synuclein-associated trafficking defects associated with early onset Parkinson's disease in a Nedd4-dependent manner.
NAB2 binds to Dedd4 side chain and does not alter its conformation or ubiquitination kinetics in vitro, does not alter its co-localization with trafficking organelles.

物理化学性质&存储条件

分子量	389.88
分子式	C23H20ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzo[d]imidazole-5-carboxamide

参考文献

1. Hatstat AK, et al. Cell Chem Biol. 2021 Jan 21;28(1):14-25.e9.

NAB2 (Nedd4 inhibitor NAB2)

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物理化学性质&存储条件

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NAB2 (Nedd4 inhibitor NAB2)

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