BC-1258 | FBXO3 inhibitor | Probechem Biochemicals

Chemical Structure : BC-1258

CAS No.: 1507370-40-2

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BC-1258 (BC1258)

货号: PC-38449Not For Human Use, Lab Use Only.

BC-1258 is a specific small molecule FBXO3 inhibitor and F-box/LRR-repeat protein 2 (FBXL2) activator, BC-1258 is sufficient to stabilize and upregulate FBXL2 levels, selectively induces Aurora B degradation in vitro and in vivo.

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25 mg	￥1580	In stock
50 mg	￥2680	In stock
100 mg	￥4380	In stock
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生物&药学活性

BC-1258 is a specific small molecule FBXO3 inhibitor and F-box/LRR-repeat protein 2 (FBXL2) activator, BC-1258 is sufficient to stabilize and upregulate FBXL2 levels, selectively induces Aurora B degradation in vitro and in vivo.
BC-1258 induced FBXL2 concentrations in a variety of cells, decreased FBXL2 substrates, including Aurora B in human leukemia cells.
BC-1258 induced apoptosis in leukemic cells by causing mitotic arrest and tetraploidy.
BC-1258 prematurely depleted Aurora B by SCFFBXL2-induced ubiquitination and degradation, BC-1258 (30 ug/ml in the drinking water) showed significant decreases in Aurora B protein levels and inhibited tumorigenesis on growth of U937 tumor implants in nude mice.

物理化学性质&存储条件

分子量	406.57
分子式	C22H22N4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1,N2-Bis[[4-(2-thiazolyl)phenyl]methyl]-1,2-ethanediamine

参考文献

1. B B Chen, et al. Cell Death Dis. 2013 Aug 8;4(8):e759.

BC-1258 (BC1258)

生物&药学活性

物理化学性质&存储条件

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BC-1258 (BC1258)

生物&药学活性

物理化学性质&存储条件

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