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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-MAN-021
MAN-021

Chemical Structure : MAN-021

CAS No.: 3109977-84-3

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MAN-021 (MAN021)

货号: PC-26895Not For Human Use, Lab Use Only.

MAN-021 is a potent TRIM21-NUP98 molecular glue triggering nuclear pore complex (NPC) degradation, promotes TRIM21 to bind the nuclear pore protein NUP98, inhibits PANC-1 cell proliferation with EC50 of 1.9 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MAN-021 is a potent TRIM21-NUP98 molecular glue triggering nuclear pore complex (NPC) degradation, promotes TRIM21 to bind the nuclear pore protein NUP98, inhibits PANC-1 cell proliferation with EC50 of 1.9 nM.

物理化学性质&存储条件

分子量 459.95
分子式 C23H27ClFN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-chloro-2-(2-(dimethylamino)ethoxy)phenyl)-6-fluoro-2-(piperazin-1-ylmethyl)quinazolin-4(3H)-one

参考文献

1. Hinshaw SM, et al. Cell Chem Biol. 2026 May 27:S2451-9456(26)00151-0.

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