JWZ-8-103

Chemical Structure : JWZ-8-103

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货号: PC-26896Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JWZ-8-103 is a potent TRIM21-targeting molecular glue triggering nuclear pore complex (NPC) degradation, is 10-fold more potent than PRLX-93936 against parental PANC-1 (IC50=9.5 nM) and H661 cells overexpressing high levels of ectopic TRIM21 (IC50 <10 nM).
JWZ-8-103 promotes a robust and rapid interaction between TRIM21 and NUP98 (apparent EC50=∼20 μM for TRIM21 PRYSPRY and NUP98 APD).
PRLX-93936 reduces levels of other short-lived prosurvival proteins, including MDM2 and c-MYC, with cell line-specific depletion patterns observed across multiple cell lines (Hs766T, KP3, MIA-PaCa2, and TRIM21 OE H661 cells), further supporting the broader consequences of NPC degradation.
JWZ-8-103 (15 or 50 mg/kg, i.p. injection) is sufficient to deplete several NUPs, effective against PANC-1 cell line–derived tumor murine xenografts.

物理化学性质&存储条件

分子量	416.88
分子式	C21H22ClFN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chloro-2-ethoxyphenyl)-6-fluoro-2-(piperazin-1-ylmethyl)quinazolin-4(3H)-one

参考文献

1. Yuan L, et al. Cancer Discov. 2025 Dec 2;15(12):2505-2529.

JWZ-8-103

生物&药学活性

物理化学性质&存储条件

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JWZ-8-103

生物&药学活性

物理化学性质&存储条件

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