FB231 | Parkin activator | Probechem Biochemicals

Chemical Structure : FB231

加入收藏

FB231 (FB-231)

货号: PC-26546Not For Human Use, Lab Use Only.

FB231 is a small molecule enhancer / activator of Parkin E3 ubiquitin ligase (PARK2) activity with EC50 of 6.75 uM in in vitro ubiquitination assay.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

FB231 is a small molecule enhancer / activator of Parkin E3 ubiquitin ligase (PARK2) activity with EC50 of 6.75 uM in in vitro ubiquitination assay.
FB231 potently activates the PINK1/Parkin pathway in combination with mitochondrial toxins.
FB231 could accentuate PINK1/Parkin mitophagy in cells exposed to low levels of mitochondrial toxins.
FB231 induces mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response, effects that result from PINK1/Parkin-independent off-target activities.

物理化学性质&存储条件

分子量	411.47
分子式	C24H21N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)bis(2-methylbenzamide)

参考文献

1. Gong Y, et al. bioRxiv [Preprint]. 2026 Apr 4:2026.04.01.715918.

2. William M Rosencrans, et al. Sci Adv. 2025 Aug 29;11(35):eady0240.

FB231 (FB-231)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

FB231 (FB-231)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.