XZA-1 | HADH activator, CBX4 inhibitor | Probechem Biochemicals

Chemical Structure : XZA-1

CAS No.: 1282141-20-1

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XZA-1 (XZA1)

货号: PC-25921Not For Human Use, Lab Use Only.

XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation.
XZA-1 activates HADH, a key enzyme in fatty acid β-oxidation, resulting in increased intracellular levels of acetoacetyl-CoA.
XZA-1 promotes acetoacetylation of CBX4 at lysine 106, thereby reducing its SUMO E3 ligase activity.
XZA-1 demonstrated antitumor effects by enhancing CBX4 K106 acetoacetylation in CBX4-overexpressing xenograft model.

物理化学性质&存储条件

分子量	256.31
分子式	C15H16N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-phenyl-5,6,7,8-tetrahydro-4H-cyclohepta[d]isoxazole-3-carboxamide

参考文献

1. Li H, et al. Cell Chem Biol. 2025 Oct 16;32(10):1249-1259.e9.

XZA-1 (XZA1)

生物&药学活性

物理化学性质&存储条件

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XZA-1 (XZA1)

生物&药学活性

物理化学性质&存储条件

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