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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-XZA-1
XZA-1

Chemical Structure : XZA-1

CAS No.: 1282141-20-1

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XZA-1 (XZA1)

货号: PC-25921Not For Human Use, Lab Use Only.

XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation.
XZA-1 activates HADH, a key enzyme in fatty acid β-oxidation, resulting in increased intracellular levels of acetoacetyl-CoA.
XZA-1 promotes acetoacetylation of CBX4 at lysine 106, thereby reducing its SUMO E3 ligase activity.
XZA-1 demonstrated antitumor effects by enhancing CBX4 K106 acetoacetylation in CBX4-overexpressing xenograft model.

物理化学性质&存储条件

分子量 256.31
分子式 C15H16N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-phenyl-5,6,7,8-tetrahydro-4H-cyclohepta[d]isoxazole-3-carboxamide

参考文献

1. Li H, et al. Cell Chem Biol. 2025 Oct 16;32(10):1249-1259.e9.

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