CLEO4-88 | GID4 binder, ACAA1 inhibitor | Probechem Biochemicals

Chemical Structure : CLEO4-88

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CLEO4-88 (CTLH receptor GID4-binding compound 88)

货号: PC-26528Not For Human Use, Lab Use Only.

CLEO4-88 is a molecular glue binder of CTLH E3 ligase substrate adaptor GID4 with KD of 5.6 uM, promotes GID4 interaction with the peroxisomal thiolase protein ACAA1 with EC50 of 12.5 nM in HTRF assays, inhibits the catalytic activity of ACAA1.

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生物&药学活性

CLEO4-88 is a molecular glue binder of CTLH E3 ligase substrate adaptor GID4 with KD of 5.6 uM, promotes GID4 interaction with the peroxisomal thiolase protein ACAA1 with EC50 of 12.5 nM in HTRF assays, inhibits the catalytic activity of ACAA1.
CLEO4-88 makes no direct contact with ACAA1.
Ternary complex formation with GID4 and CLEO4-88 inhibits ACAA1 thiolytic activity with IC50 of 1.8 uM.
CLEO4-88 can act as a molecular glue to drive interaction of GID4 and ACAA1 in live cells.

物理化学性质&存储条件

分子量	538.66
分子式	C28H34N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((S)-2-(2-((2,4-dimethoxybenzyl)amino)acetamido)-2-(thiophen-2-yl)acetamido)-N-methyl-4-phenylbutanamide

参考文献

1. Chana CK, et al. Nat Chem Biol. 2026 Apr 9. doi: 10.1038/s41589-026-02183-4.

CLEO4-88 (CTLH receptor GID4-binding compound 88)

生物&药学活性

物理化学性质&存储条件

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CLEO4-88 (CTLH receptor GID4-binding compound 88)

生物&药学活性

物理化学性质&存储条件

参考文献

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