NX-1013 (NX1013)

Chemical Structure : NX-1013

加入收藏

货号: PC-26463Not For Human Use, Lab Use Only.

NX-1013 is a potent, specific inhibitor of Casitas B-lineage lymphoma-b (Cbl-b) E3 ubiquitin ligase with binding Kd of 0.87 nM and 3.4 nM for CBL-B and CBL, and IC50 of 0.51 nM and 1.7 nM for CBLB and CBL.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NX-1013 is a potent, specific inhibitor of Casitas B-lineage lymphoma-b (Cbl-b) E3 ubiquitin ligase with binding Kd of 0.87 nM and 3.4 nM for CBL-B and CBL, and IC50 of 0.51 nM and 1.7 nM for CBLB and CBL.

NX-1013 is a highly effective inhibitor of EGFR ubiquitination.

NX-1013 strongly inhibits endocytic trafficking of EGFR.

NX-1013 inhibits clathrin-mediated internalization of activated EGFR.

物理化学性质&存储条件

分子量	553.63
分子式	C30H34F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(((3S,5R)-3,5-dimethylpiperidin-1-yl)methyl)-2-(3-(3-((4-methyl-4H-1,2,4-triazol-3-yl)methyl)oxetan-3-yl)phenyl)-4-(trifluoromethyl)isoindolin-1-one

参考文献

1. Itziar Pinilla-Macua, et al. Proc Natl Acad Sci U S A. 2026 Mar 31;123(13):e2524664123.

NX-1013 (NX1013)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NX-1013 (NX1013)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.