| Cat. No. |
Product Name |
Information |
| PC-43513 |
Gossypol
BCL-2 inhibitor
|
Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
| PC-42244 |
S63845
Mcl-1 inhibitor
|
S63845 is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM). |
| PC-47486 |
Bax inhibitor peptide V5
Bax inhibitor
|
Bax inhibitor peptide V5 (Val-Pro-Met-Leu-Lys, BIP-V5) is cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. |
| PC-45901 |
ABT-737
BCL-2 inhibitor
|
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively. |
| PC-24290 |
WEHI-3773
VDAC2-BAX inhibitor
|
WEHI-3773 is a small molecule inhibitor of interaction between VDAC2 and BAX, inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria. |
| PC-24151 |
Lonitoclax
BCL-2 inhibitor
|
Lonitoclax is a potent, selective next generation BCL-2 inhibitor, a key pro-survival protein that is overexpressed in many cancers, for the treatment of AML and CLL. |
| PC-23978 |
Bcl-3 inhibitor A27
Bcl-3 inhibitor
|
Bcl-3 inhibitor A27 is a specific small molecule inhibitor of proto-oncogene Bcl-3, inhibits Bcl-3-mediated cyclin D1 expression and promoter activity, affects the binding between Bcl-3 and the NF-κB transcription factor p50, without affecting the classical NF-κB activation. |
| PC-23835 |
AMG-397
Mcl-1 inhibitor
|
Murizatoclax (AMG-397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor with Ki of 15 pM. |
| PC-23834 |
ABBV-467
Mcl-1 inhibitor
|
ABBV-467 is a highly potent and selective MCL-1 inhibitor with TR-FRET Ki of <0.01 nM, >25,000-fold seletive over other BCL-2 family proteins BCL-XL, BCL-2, BCL-W, and BCL2-A1. |
| PC-23607 |
BFL1 inhibitor 20
BFL1 inhibitor
|
BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1. |
| PC-23094 |
Lacutoclax
Bcl-2 inhibitor
|
Lacutoclax (LP-108) is a highly potent and selective inhibitor of BCL-2 with comparable or more potent in vitro inhibitory activity compared to venetoclax. |
| PC-23065 |
Bfl-1 inhibitor (R,R,S)-26
Bfl-1 inhibitor
|
Bfl-1 inhibitor (R,R,S)-26 is a potent, selective, covalent, cell active Bfl-1 inhibitor with IC50 of 22 nM, shows no activity against Bcl-xl, Bcl-2 and Mcl-1 (IC50>30 uM). |
