| Cat. No. |
Product Name |
Information |
| PC-45041 |
MIM1
Mcl-1 inhibitor
|
MIM1 is a potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1. |
| PC-42277 |
Navitoclax
Bcl-2 inhibitor
|
Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w. |
| PC-42756 |
Obatoclax
Bcl-2 inhibitor
|
Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1. |
| PC-45490 |
UMI-77
Mcl-1 inhibitor
|
UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM. |
| PC-45314 |
Gossypol acetic acid
BCL-2 inhibitor, LRPPRC inhibitor
|
Gossypol acetic acid ((±)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
| PC-44439 |
AT-101
BCL-2 inhibitor
|
AT-101 ((R)-(-)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
| PC-43513 |
Gossypol
BCL-2 inhibitor
|
Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
| PC-42244 |
S63845
Mcl-1 inhibitor
|
S63845 is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM). |
| PC-47486 |
Bax inhibitor peptide V5
Bax inhibitor
|
Bax inhibitor peptide V5 (Val-Pro-Met-Leu-Lys, BIP-V5) is cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. |
| PC-45901 |
ABT-737
BCL-2 inhibitor
|
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively. |
| PC-26415 |
BAX activator 27c
BAX activator
|
BAX activator 27c is a selective small molecule BAX activator with binding IC50 of 0.3 uM in competitive FP binding assays, shows >40-fold selectivity over other antiapoptotic BCL-2 family proteins. |
| PC-26343 |
Nexatoclax
Bcl-2/xL inhibitor
|
Nexatoclax (LP-118) is a potent small molecule inhibitor of Bcl-2 and Bcl-xL (IC50=10.1 nM), more potent than venetoclax and with added advantage of selectively binding to Bcl-xL while minimizing the platelet toxicity. |
