| Cat. No. |
Product Name |
Information |
| PC-73094 |
WEHI-9625
BAK inhibitor
|
WEHI-9625 (WEHI9625) is a small molecule selectively binds to VDAC2 and promotes its ability to inhibits apoptosis (EC50=69 nM) driven by murine BAK, selectively blocks murine BAK-mediated apoptosis. |
| PC-72944 |
BTSA1
BAX activator
|
BTSA1 (BAX Trigger Site Activator 1) is a potent, selective, orally bioavailable BAX trigger site activator, binds with high affinity (EC50=144 nM) and specificity to the N-terminal activation site. |
| PC-72943 |
BTSA1.2
BAX activator
|
BTSA1.2 is a potent, selective, orally bioavailable BAX activator, demonstrated increased binding to BAX (IC50=149 nM) compared to BTSA1 (IC50=247 nM). |
| PC-72541 |
BFL-1 inhibitor 4E14
BFL-1 inhibitor
|
4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction). |
| PC-72519 |
CCT369347
BCL-6 inhibitor
|
CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM. |
| PC-72311 |
Lisaftoclax
BCL-2 inhibitor
|
Lisaftoclax (APG-2575) is a novel BCL-2 selective inhibitor with binding Ki of < 0.1/0.1 nM for Bcl-2/Bcl-XL, no binding affinity against BCL-W/MCL-1. |
| PC-72240 |
BAX inhibitor BAI1
BAX inhibitor
|
BAX inhibitor BAI1 (BAI1) is a small-molecule allosteric inhibitor of BAX, bind directly to BAX and inhibits tBID-induced BAX-mediated membrane permeabilization with IC50 of 3.4 uM. |
| PC-38265 |
EU-5346
Mcl-1 inhibitor
|
EU-5346 (ML311) is a small molecule Mcl-1 inhibitor with IC50 of 0.31 uM, potently and selectively disrupts Mcl-1/Bim interaction. |
| PC-35716 |
BCL6 inhibitor 14
BCL6 inhibitor
|
BCL6 inhibitor 14 is a potent BCL-6 inhibitor with FRET IC50 of 63 nM.. |
| PC-35691 |
S64315
Mcl-1 inhibitor
|
MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities. |
| PC-35655 |
VU661013
Mcl-1 inhibitor
|
VU661013 (VU-661013) is a novel potent, selective MCL-1 inhibitor with Ki of 97 pM (human MCL-1) in TR-FRET assay, shows no significant inhibition on BCL-xL (Ki>40 uM) or BCL-2 (Ki=0.73 uM). |
| PC-35590 |
BXI-72
BCL-XL inhibitor
|
BXI-72 (NSC334072, Hoechst 33342) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM). |
