WK369 | BCL6-BTB inhibitor | Probechem Biochemicals

Chemical Structure : WK369

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WK369 (WK 369, WK-369)

货号: PC-21609Not For Human Use, Lab Use Only.

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50 mg		Get quote
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1 g		Get quote

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生物&药学活性

WK369 (WK-369) is a specific small molecule inhibitor of BCL6, directly binds to the BCL6-BTB domain (SPR KD=2.24 uM) and blocks the interaction between BCL6 and SMRT with IC50 of 0.32 uM in HTRF assays.
WK369 exhibits excellent binding affinities to BCL6-BTB domain with IC50 of <2 uM in HTRF assays, 120 times higher potent than that of FX1 (Cat# PC-60927).
WK369 inhibits the transcriptional repressor activity of BCL6-BTB in a dose dependent manner in vitro and in vivo, but without any effect on the other BTB zinc finger repressors (Kaiso and PLZF).
WK369 significantly reactivates multiple BCL6-target genes including ATR, CD69, p53 and CDKN1A.
WK369 inhibits ovarian cancer cell growth, migration and induces apoptosis.
WK369 prevents ovarian cancer growth, suppresses ovarian cancer intra-abdominal metastasis in vivo.
WK369 sensitizes ovarian cancer to chemotherapy on SKOV3 xenograft mouse models, inhibits AKT and MEK/ERK signaling pathway by targeting BCL6.

物理化学性质&存储条件

分子量	369.40
分子式	C19H20FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((2-((3S,5R)-3,5-dimethylpiperazin-1-yl)-5-fluoropyrimidin-4-yl)amino)-2H-chromen-2-one

参考文献

1. Min Wu, et al. Int J Biol Sci. 2024 Jan 1;20(2):486-501.

WK369 (WK 369, WK-369)

生物&药学活性

物理化学性质&存储条件

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WK369 (WK 369, WK-369)

生物&药学活性

物理化学性质&存储条件

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