| Cat. No. |
Product Name |
Information |
| PC-38265 |
EU-5346
Mcl-1 inhibitor
|
EU-5346 (ML311) is a small molecule Mcl-1 inhibitor with IC50 of 0.31 uM, potently and selectively disrupts Mcl-1/Bim interaction. |
| PC-36080 |
Jaceosidin
Bax activator
|
Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties, activates Bax and down-regulates Mcl-1 and c-FLIP expression. |
| PC-35716 |
BCL6 inhibitor 14
BCL6 inhibitor
|
BCL6 inhibitor 14 is a potent BCL-6 inhibitor with FRET IC50 of 63 nM.. |
| PC-35691 |
S64315
Mcl-1 inhibitor
|
MIK665 (S64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities. |
| PC-35655 |
VU661013
Mcl-1 inhibitor
|
VU661013 (VU0661013) is a novel potent, selective MCL-1 inhibitor with Ki of 97 pM (human MCL-1) in TR-FRET assay, shows no significant inhibition on BCL-xL (Ki>40 uM) or BCL-2 (Ki=0.73 uM). |
| PC-35590 |
BXI-72
BCL-XL inhibitor
|
BXI-72 (NSC334072, Hoechst 33342) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM). |
| PC-35318 |
BRD1991
Beclin 1/Bcl-2 inhibitor
|
BRD1991 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity. |
| PC-35317 |
SW076956
Beclin 1/Bcl-2 inhibitor
|
SW076956 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity. |
| PC-35316 |
SW063058
Beclin 1/Bcl-2 inhibitor
|
SW063058 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity. |
| PC-43514 |
Apogossypol
BCL-2 inhibitor
|
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively. |
| PC-63502 |
S55746
BCL-2 inhibitor
|
S55746 (BCL201, Servier-1) is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1. |
| PC-63501 |
S55746 hydrochloride
BCL-2 inhibitor
|
S55746 (BCL201, Servier-1) hydrochloride is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1. |
