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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-ABBV-167
ABBV-167

Chemical Structure : ABBV-167

CAS No.: 1351456-78-4

ABBV-167 (ABBV167)

货号: PC-20511Not For Human Use, Lab Use Only.

ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax (Cat. PC-49764), shows significantly increased water solubility to venetoclax, demonstrates a lower food effect with respect to venetoclax.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax (Cat. PC-49764), shows significantly increased water solubility to venetoclax, demonstrates a lower food effect with respect to venetoclax.

    物理化学性质&存储条件

    分子量 978.45
    分子式 C46H53ClN7O11PS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN(COP(O)(O)=O)C8=NC=CC8=C7

    参考文献

    1. Ahmed Hamed Salem, et al. Mol Cancer Ther. 2021 Jun;20(6):999-1008.

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