| Cat. No. |
Product Name |
Information |
| PC-60951 |
BI-5273
|
BI-5273 is a negative control compound of BI-3802 and BI-3812, which are potent and efficacious BCL6 degrader and inhibitor, respectively. |
| PC-60950 |
BI-3812
BCL6 inhibitor
|
BI-3812 is a highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM. |
| PC-60949 |
BI-3802
BCL6 inhibitor
|
BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM. |
| PC-60941 |
DAN004
Bax inhibitor
|
DAN 004 is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM. |
| PC-60940 |
MSN-125
Bax inhibitor
|
MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM. |
| PC-60927 |
FX1
BCL6 inhibitor
|
FX1 (BCL6 inhibitor FX1) is a potent, specific BCL6 BTB domain inhibitor with Kd of 7 uM, binds with a greater affinity than the natural BCL6 ligand SMRT (Kd=30 uM). |
| PC-60926 |
BCL6 inhibitor 79-6
BCL6 inhibitor
|
BCL6 inhibitor 79-6 (Compound 79-6) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM. |
| PC-60925 |
SMBA1
BAX activator
|
SMBA1 is a potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation. |
| PC-60924 |
CYD-2-11
Bax agonist
|
CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM). |
| PC-60923 |
BTC-8
Bax activator
|
BTC-8 is a derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM. |
| PC-60922 |
Bax activator compound 106
Bax activator
|
Bax activator compound 106 (ZINC14750348) is a specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis. |
| PC-60281 |
BDA-366
BCL-2 inhibitor
|
BDA-366 (NSC639366) is a potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM. |
