S44563 | Bcl-2/Bcl-XL inhibitor | Probechem Biochemicals

Chemical Structure : S44563

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S44563 (S 44563)

货号: PC-61989Not For Human Use, Lab Use Only.

S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively.

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生物&药学活性

S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively.
S44563 induces in vitro apoptosis of melanoma xenograft-derived cell lines MP41, MM26, and MM66 with IC50 of 4, 7 and 6 uM.
S44563 increases the efficacy of fotemustine in either concomitant or sequential combinations or indeed subsequent to fotemustine in vivo, also enhance radiosensitivity of SCLC cells in vitro and in vivo.

物理化学性质&存储条件

分子量	839.467
分子式	C44H47ClN6O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4aR)-3-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxamide

参考文献

1. Ashkenazi A, et al. Nat Rev Drug Discov. 2017 Apr;16(4):273-284.

2. Némati F, et al. PLoS One. 2014 Jan 13;9(1):e80836.

3. Loriot Y, et al. Cell Death Dis. 2014 Sep 18;5:e1423.

S44563 (S 44563)

生物&药学活性

物理化学性质&存储条件

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S44563 (S 44563)

生物&药学活性

物理化学性质&存储条件

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