DAN 004 |CAS: 2251049-11-1 Probechem Biochemicals

Chemical Structure : DAN004

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DAN004 (DAN 004; DAN-004)

货号: PC-60941Not For Human Use, Lab Use Only.

DAN 004 is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM.

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生物&药学活性

DAN 004 is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 0.7 uM.
DAN 004 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.

物理化学性质&存储条件

分子量	494.433
分子式	C26H28BrN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-((3-aminopropyl)(4-bromobenzyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide

参考文献

1. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.

DAN004 (DAN 004; DAN-004)

生物&药学活性

物理化学性质&存储条件

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DAN004 (DAN 004; DAN-004)

生物&药学活性

物理化学性质&存储条件

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