(-) BI97D6 |CAS:1256724-10-3 Probechem Biochemicals

Chemical Structure : (-) BI97D6

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(-) BI97D6 (BI97D6, BI112D1)

货号: PC-61318Not For Human Use, Lab Use Only.

(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.

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生物&药学活性

(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.
(-) BI97D6 effectively inhibits cell growth in the PC-3 human prostate cancer and H23 human lung cancer cell lines with EC50 of 0.22 and 0.14 uM, respectively.
(-) BI97D6 effectively induces apoptosis in the BP3 human lymphoma cell lines.
(-) BI97D6 displays in vivo efficacy in a prostate cancer xenograft model in mice.
(-) BI97D6 also overcomes ABT-737 resistance in AML, kills AML leukemia stem/progenitor cells while largely sparing normal hematopoietic stem/progenitor cells.

物理化学性质&存储条件

分子量	586.596
分子式	C36H26O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5'-dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',4,4'-tetraone

参考文献

1. Wei J, et al. Front Oncol. 2011 Sep 30;1:28.

2. Pan R, et al. Blood. 2015 Jul 16;126(3):363-72.

3. Wei J, et al. J Med Chem. 2009 Jul 23;52(14):4511-23.

(-) BI97D6 (BI97D6, BI112D1)

生物&药学活性

物理化学性质&存储条件

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(-) BI97D6 (BI97D6, BI112D1)

生物&药学活性

物理化学性质&存储条件

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