AZD 4320 |CAS:1357576-48-7 Probechem Biochemicals

Chemical Structure : AZD 4320

CAS No.: 1357576-48-7

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AZD 4320 (AZD4320)

货号: PC-61988Not For Human Use, Lab Use Only.

AZD4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor with IC50 of <1 nM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

AZD4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor with IC50 of <1 nM.
AZD4320 induces caspase-3 cleavage and cell death in both Bcl-2-driven (SuDHL4, GI50 <50 nM) and Bcl-xL-driven (SuDHL8, GI50 <50 nM) diffuse large B-cell lymphoma (DLBCL) cell lines.
AZD4320 treatment results in complete and sustained (>24 days) tumor regressions in a mouse RS4;11 acute lymphocytic leukemia xenograft model (20 mg/kg, i.v.).

物理化学性质&存储条件

分子量	945.525
分子式	C45H48ClF3N4O7S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-((R)-(4'-chloro-[1,1'-biphenyl]-2-yl)(hydroxy)methyl)piperidin-1-yl)-N-((4-(((R)-4-((2-hydroxyethyl)(methyl)amino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

参考文献

1. Ashkenazi A, et al. Nat Rev Drug Discov. 2017 Apr;16(4):273-284.
2. Hennessy, E. J. et al. Discovery of potent inhibitors of the antiapoptotic proteins Bcl-2 and Bcl-xL, resulting in the identification of a clinical candidate for the treatment of cancer (AZD4320). ACS Medicinal Chemistry annual meeting 2015.

AZD 4320 (AZD4320)

生物&药学活性

物理化学性质&存储条件

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AZD 4320 (AZD4320)

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