| Cat. No. |
Product Name |
Information |
| PC-26239 |
Bfl-1 inhibitor 25
Bfl-1 inhibitor
|
Bfl-1 inhibitor 25 is a potent and irreversible cellular probe inhibitor of Bcl-2 family member Bfl-1 with FRET IC50 of 16 nM, inhibits SU-DHL-1 cell viability with EC50 of 0.21 uM. |
| PC-25524 |
YC137
BCL-2 inhibitor
|
YC137 is a specific small molecule inhibitor of Bcl-2 with Ki of 1.3 uM, with no affinity for Bcl-xL (Ki>100 uM), inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. |
| PC-25337 |
BCL6 inhibitor YK01
BCL6 inhibitor
|
BCL6 inhibitor YK01 is a potent, specific small molecule inhibitor of BCL6-BTB with binding IC50 of 11.7 nM, directly binds to BCL6BTB with SPR KD of 148 nM, inhibits BCL6 transcriptional activity. |
| PC-25072 |
Mesutoclax
BCL-2 inhibitor
|
Mesutoclax (ICP-248) is a highly selective and potent, orally active BCL2 inhibitor. |
| PC-25038 |
Dalvotoclax
BCL-2 inhibitor
|
Dalvotoclax is a potent, selective inhibitor of anti-apoptotic protein Bcl-2. |
| PC-24935 |
Asaretoclax
BCL-2 inhibitor
|
Asaretoclax (ZN-d5) is a potent, selective and orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. |
| PC-24442 |
Foselutoclax
BCL-xL inhibitor
|
Foselutoclax (UBX1325) is a senolytic small-molecule inhibitor of BCL-xL. |
| PC-24290 |
WEHI-3773
VDAC2-BAX inhibitor
|
WEHI-3773 is a small molecule inhibitor of interaction between VDAC2 and BAX, inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria. |
| PC-24151 |
Lonitoclax
BCL-2 inhibitor
|
Lonitoclax is a potent, selective next generation BCL-2 inhibitor, a key pro-survival protein that is overexpressed in many cancers, for the treatment of AML and CLL. |
| PC-23978 |
Bcl-3 inhibitor A27
Bcl-3 inhibitor
|
Bcl-3 inhibitor A27 is a specific small molecule inhibitor of proto-oncogene Bcl-3, inhibits Bcl-3-mediated cyclin D1 expression and promoter activity, affects the binding between Bcl-3 and the NF-κB transcription factor p50, without affecting the classical NF-κB activation. |
| PC-23835 |
AMG-397
Mcl-1 inhibitor
|
Murizatoclax (AMG-397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor with Ki of 15 pM. |
| PC-23834 |
ABBV-467
Mcl-1 inhibitor
|
ABBV-467 is a highly potent and selective MCL-1 inhibitor with TR-FRET Ki of <0.01 nM, >25,000-fold seletive over other BCL-2 family proteins BCL-XL, BCL-2, BCL-W, and BCL2-A1. |
