| Cat. No. |
Product Name |
Information |
| PC-22977 |
BRD-810
Mcl-1 inhibitor
|
BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein. |
| PC-22111 |
TUDCA
Bax inhibitor
|
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis. |
| PC-22106 |
BAM7
Bax activator
|
BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death.
BAM7 is selective for the BH3-binding site on BAX. |
| PC-22105 |
CBI1
Bax inhibitor
|
Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis. |
| PC-21609 |
WK369
BCL6-BTB inhibitor
|
WK369 (WK-369) is a specific small molecule inhibitor of BCL6, directly binds to the BCL6-BTB domain (SPR KD=2.24 uM) and blocks the interaction between BCL6 and SMRT with IC50 of 0.32 uM in HTRF assays. |
| PC-21258 |
M109S
Bax inhibitor
|
M109S is a small molecule protecting cells from mitochondria-dependent apoptosis wtih EC50 of 23.4 nM in iBax cells, directly interacts with Bax (Kd=153 nM, MST assay) and inhibits Bax activation. |
| PC-21117 |
PDCD2 ligand 7e
PDCD2 modulator
|
PDCD2 ligand 7e is a small molecule that may directly bind to PDCD2, rescues PDCD2 degradation induced by PDCD2 degrader 10e. |
| PC-21059 |
WK499
BCL-6 inhibitor
|
WK499 (WK-499) is a small molecule inhibitor of BCL6 with IC50 of 11.7 nM in HTRF assay, directly binds to BCL6 BTB (SPR KD=148 nM), inhibits the BCL6-mediated transcriptional repression activity. |
| PC-20626 |
CCT373567
BCL6 inhibitor
|
CCT373567 is a potent, selective and cell-active BCL6 inhibitor with IC50 of 2.9 nM in TR-FRET assays, and 25.9 nM in NanoBRET cellular inhibition assays. |
| PC-49189 |
DC-B01
BCL2 BH4 inhibitor
|
DC-B01 is a novel small molecule BCL-2 inhibitor that binds to the BH4 domain with KD of 2.16 uM, disrupts the BCL-2/c-Myc interaction and consequently suppresses the transcriptional activity of c-Myc. |
