| Cat. No. |
Product Name |
Information |
| PC-60153 |
Mcl1-IN-26
|
Mcl-1-IN-26 is a potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays. |
| PC-70089 |
AMG-176
Mcl-1 inhibitor
|
AMG-176 (AMG176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity (Ki=0.06 nM) and selectivity to the BH3-binding groove of Mcl-1. |
| PC-45672 |
Tauroursodeoxycholic acid sodium
BAX inhibitor
|
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis. |
| PC-45700 |
A-1331852
BCL-XL inhibitor
|
A-1331852 (A1331852) is a potent and selective BCL-XL inhibitor (Ki<10 pM). |
| PC-45687 |
A-1155463
BCL-XL inhibitor
|
A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM). |
| PC-42125 |
BH3I-1
Bcl-2 inhibitor
|
BH3I-1 (BHI1) is a small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay. |
| PC-45041 |
MIM1
Mcl-1 inhibitor
|
MIM1 is a potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1. |
| PC-42277 |
Navitoclax
Bcl-2 inhibitor
|
Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w. |
| PC-42756 |
Obatoclax
Bcl-2 inhibitor
|
Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1. |
| PC-45490 |
UMI-77
Mcl-1 inhibitor
|
UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM. |
| PC-45314 |
Gossypol acetic acid
BCL-2 inhibitor
|
Gossypol acetic acid ((±)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
| PC-44439 |
AT-101
BCL-2 inhibitor
|
AT-101 ((R)-(-)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
