| Cat. No. |
Product Name |
Information |
| PC-60926 |
BCL6 inhibitor 79-6
BCL6 inhibitor
|
BCL6 inhibitor 79-6 (Compound 79-6) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM. |
| PC-60925 |
SMBA1
BAX activator
|
SMBA1 is a potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation. |
| PC-60924 |
CYD-2-11
Bax agonist
|
CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM). |
| PC-60923 |
BTC-8
Bax activator
|
BTC-8 is a derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM. |
| PC-60922 |
Bax activator compound 106
Bax activator
|
Bax activator compound 106 (ZINC14750348) is a specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis. |
| PC-60281 |
BDA-366
BCL-2 inhibitor
|
BDA-366 (NSC639366) is a potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM. |
| PC-60153 |
Mcl1-IN-26
|
Mcl-1-IN-26 is a potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays. |
| PC-70089 |
Tapotoclax
Mcl-1 inhibitor
|
Tapotoclax (AMG-176) is a novel, potent and selective Mcl-1 inhibitor that binds with high affinity (Ki=0.06 nM) and selectivity to the BH3-binding groove of Mcl-1. |
| PC-45672 |
Tauroursodeoxycholic acid sodium
BAX inhibitor
|
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis. |
| PC-45700 |
A-1331852
BCL-XL inhibitor
|
A-1331852 (A1331852) is a potent and selective BCL-XL inhibitor (Ki<10 pM). |
| PC-45687 |
A-1155463
BCL-XL inhibitor
|
A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM). |
| PC-42125 |
BH3I-1
Bcl-2 inhibitor
|
BH3I-1 (BHI1) is a small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay. |
