Apogossypol |CAS:66389-74-0 Probechem Biochemicals

Chemical Structure : Apogossypol

加入收藏

Apogossypol ((+)-Apogossypol;NSC 736630)

货号: PC-43514Not For Human Use, Lab Use Only.

Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.

规格	价格	库存	数量
5 mg		Get quote
25 mg		Get quote
100 mg		Get quote
500 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.
Apogossypol induces apoptosis of tumor cell lines, inhibits the growth and proliferation of prostate cancer cells by downregulating Bcl‑2 protein expression and activating caspase‑3 and ‑8.
Apogossypol displays superior activity to gossypol in terms of reducing splenomegaly and reducing B-cell counts in spleens of Bcl-2-transgenic mice.

物理化学性质&存储条件

分子量	462.53
分子式	C28H30O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-

参考文献

1. Becattini B, et al. Chem Biol. 2004 Mar;11(3):389-95.

2. Wei J, et al. Mol Cancer Ther. 2009 Apr;8(4):904-13.

3. Kitada S, et al. Blood. 2008 Mar 15;111(6):3211-9.

4. Zhan W, et al. Mol Med Rep. 2015 Jun;11(6):4142-8.

Apogossypol ((+)-Apogossypol;NSC 736630)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Apogossypol ((+)-Apogossypol;NSC 736630)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.