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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-Pyridoclax
Pyridoclax

Chemical Structure : Pyridoclax

CAS No.: 1651890-44-6

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Pyridoclax (MR-29072, MR29072)

货号: PC-43096Not For Human Use, Lab Use Only.

Pyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction.

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25 mg ￥2180 In stock
50 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction.
Pyridoclax (MR29072) strongly sensitizes ovarian cancer chemoresistant IGROV1-R10 cells to Bcl-xL targeting siRNA and ABT-737, leading to massive apoptosis, can not induce cell death as single agents.
Pyridoclax (MR29072) induces ER stress and modifies Bcl-2 family expression, but its cytotoxic effect does not require these events.

物理化学性质&存储条件

分子量 426.5118
分子式 C29H22N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-3'-methyl-3''-styryl-3,2':5',2'':5'',3'''-quaterpyridine

参考文献

1. Gloaguen C, et al. J Med Chem. 2015 Feb 26;58(4):1644-68.

2. Groo AC, et al. Eur J Pharm Sci. 2017 Jan 15;97:218-226.

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