Sabutoclax |CAS:1228108-65-3 Probechem Biochemicals

Chemical Structure : Sabutoclax

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Sabutoclax (BI-97C1)

货号: PC-63211Not For Human Use, Lab Use Only.

Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor that inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31, 0.32, 0.20 and 0.62 uM.

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生物&药学活性

Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor that inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31, 0.32, 0.20 and 0.62 uM.
Sabutoclax (BI-97C1) potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines withEC50 of 0.13, 0.56, and 0.049 uM, respectively.
Sabutoclax (BI-97C1) displays superior single-agent antitumor efficacy in prostate cancer mouse xenograft model.

物理化学性质&存储条件

分子量	700.788
分子式	C42H40N2O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-,(1R)-

参考文献

1. Wei J, et al. J Med Chem. 2010 May 27;53(10):4166-76.

2. Dash R, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8785-90.

3. Azab B, et al. J Cell Physiol. 2012 May;227(5):2145-53.

4. Goff DJ, et al. Cell Stem Cell. 2013 Mar 7;12(3):316-28.

Sabutoclax (BI-97C1)

生物&药学活性

物理化学性质&存储条件

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Sabutoclax (BI-97C1)

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