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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-S55746
S55746

Chemical Structure : S55746

CAS No.: 1448584-12-0

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S55746 (BCL201;BCL-201;S 55746;S-55746;Servier-1)

货号: PC-63502Not For Human Use, Lab Use Only.

S55746 (BCL201, Servier-1) is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: 99.5% (LCMS) Select Batch:

生物&药学活性

S55746 (BCL201, Servier-1) is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1.
S55746 potently induces RS4;11 cell killing after 72 h of treatment with an IC50 of 71.6 nM, exhibits a much weaker activity in H146 (IC50 1.7 μM), a BCL-XL-dependent cell line.
S55746 concentration-dependently disrupts the BCL-2/BAX complex in RS4;11 cells, selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.
S55746 nduces cell death in a panel of non-Hodgkin lymphoma cells.
S55746 inhibits xenograft growth in RS4;11 and Toledo models.

物理化学性质&存储条件

分子量 710.831
分子式 C43H42N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(4-hydroxyphenyl)-3-(6-(3-(morpholinomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzo[d][1,3]dioxol-5-yl)-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide

参考文献

1. Casara P, et al. Oncotarget. 2018 Apr 13;9(28):20075-20088.

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