HA14-1 | Bcl-2 inhibitor | Probechem Biochemicals

Chemical Structure : HA14-1

CAS No.: 65673-63-4

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HA14-1 (HA-14-1, HA 14-1)

货号: PC-42826Not For Human Use, Lab Use Only.

HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells.

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10 mg	￥380	In stock
25 mg	￥580	In stock
100 mg	￥980	In stock
250 mg		Get quote
250 mg		Get quote

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生物&药学活性

HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells.
HA14-1 effectively induces apoptosis of HL-60 cells overexpressing Bcl-2 protein associated with the decrease in mitochondrial membrane potential and activation of caspase-9 followed by caspase-3.
HA14-1 strongly induces the death of NIH 3T3 (Apaf-1(+/+)) cells.

物理化学性质&存储条件

分子量	409.2313
分子式	C17H17BrN2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-.alpha.-cyano-3-(ethoxycarbonyl)-, ethyl ester, (.alpha.R,4R)-rel-

参考文献

1. Wang JL, et al. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7124-9.

2. Milella M, et al. Blood. 2002 May 1;99(9):3461-4.

3. Chen J, et al. Mol Cancer Ther. 2002 Oct;1(12):961-7.

4. Lickliter JD, et al. Leukemia. 2003 Nov;17(11):2074-80.

HA14-1 (HA-14-1, HA 14-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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HA14-1 (HA-14-1, HA 14-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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