WEHI-3773

Chemical Structure : WEHI-3773

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货号: PC-24290Not For Human Use, Lab Use Only.

WEHI-3773 is a small molecule inhibitor of interaction between VDAC2 and BAX, inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria.

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生物&药学活性

WEHI-3773 is a small molecule inhibitor of interaction between VDAC2 and BAX, inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria.
WEHI-3773 inhibits BAX activation and translocation to limit MOMP and protect cells.
WEHI-3773 inhibits VDAC2-mediated BAX recruitment to mitochondria.
WEHI-3773 primes BAK activation by destabilizing its interaction with VDAC2.
WEHI-3773 targets VDAC2 to modulate BAK and BAX.
WEHI-3773 overcomes venetoclax resistance in leukemic cells.

物理化学性质&存储条件

分子量	618.69
分子式	C30H22N10O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4,4',6,6'-tetraamino-1,1'-bis(4-(methylthio)phenyl)-2,2'-dioxo-1,1',2,2'-tetrahydro-[3,3'-bipyrrolo[2,3-b]pyridinylidene]-5,5'-dicarbonitrile

参考文献

1. Li K, et al. Sci Adv. 2025 Mar 7;11(10):eadr8146.

WEHI-3773

生物&药学活性

物理化学性质&存储条件

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WEHI-3773

生物&药学活性

物理化学性质&存储条件

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