Bcl-3 inhibitor A27

Chemical Structure : Bcl-3 inhibitor A27

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货号: PC-23978Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Bcl-3 inhibitor A27 is a specific small molecule inhibitor of proto-oncogene Bcl-3, inhibits Bcl-3-mediated cyclin D1 expression and promoter activity, affects the binding between Bcl-3 and the NF-κB transcription factor p50, without affecting the classical NF-κB activation.
A27 could also reduce cyclin D1 expression at the RNA and protein levels in human and mouse melanoma cell lines without affecting the expression of Bcl-3.
A27 reduces cyclin D1 promoter activity.
A27 reduces cell migration and invasion in melanoma cells.
A27 (25 mg /kg) causes reduced melanoma tumour growth in vivo.

物理化学性质&存储条件

分子量	321.18
分子式	C13H6Cl2N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((4-(3,4-Dichlorophenyl) thiazol-2-yl) amino) methylene) malononitrile

参考文献

1. Saamarthy K, et al. Br J Pharmacol. 2025 Feb 12. doi: 10.1111/bph.17467.