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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-BI-3812
BI-3812

Chemical Structure : BI-3812

CAS No.: 2166387-64-8

BI-3812 (BI3812;BI 3812)

货号: PC-60950Not For Human Use, Lab Use Only.

BI-3812 is a highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BI-3812 is a highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
BI-3812 inhibits the BCL6/Co-repressor complex formation with IC50 of 40 nM in vitro.

物理化学性质&存储条件

分子量 558.036
分子式 C26H32ClN7O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide

参考文献

1. Kerres N, et al. Cell Rep. 2017 Sep 19;20(12):2860-2875.

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