AZD5991 | Mcl-1 inhibitor | Probechem Biochemicals

Chemical Structure : AZD5991

CAS No.: 2143061-81-6

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AZD5991 (AZD-5991)

货号: PC-61404Not For Human Use, Lab Use Only.

AZD5991 (AZD-5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity (SPR Kd=0.17 nM).

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

AZD5991 (AZD-5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity (SPR Kd=0.17 nM).
AZD5991 promotes rapid apoptosis in Mcl-1-dependent cell lines (GI50=10 nM in multiple myeloma cell lines), disrupts Mcl-1/Bak complex.
AZD5991 completely causes tumor regression in several mouse xenograft models after a single tolerated dose.

物理化学性质&存储条件

分子量	672.259
分子式	C35H34ClN5O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-16-chloro-11,21,25,61-tetramethyl-11H,21H,61H-10-oxa-4,8-dithia-1(7,3)-indola-2(4,3),6(3,5)-dipyrazola-9(3,1)-naphthalenacyclotridecaphane-12-carboxylic acid

参考文献

1. Alexander W. Hird, et al. Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers, AACR. DOI: 10.1158/1538-7445.

AZD5991 (AZD-5991)

生物&药学活性

物理化学性质&存储条件

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AZD5991 (AZD-5991)

生物&药学活性

物理化学性质&存储条件

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