MI-238 | Mcl-1 inhibitor | Probechem Biochemicals

Chemical Structure : MI-238

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MI-238 (MI 238)

货号: PC-49852Not For Human Use, Lab Use Only.

MI-238 (MI 238) is a potent and specific Mcl-1 inhibitor with Ki of 0.45 uM to human Mcl-1 protein in FP assays, disrupts the association of Mcl-1 with BH3-only proteins.

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生物&药学活性

MI-238 (MI 238) is a potent and specific Mcl-1 inhibitor with Ki of 0.45 uM to human Mcl-1 protein in FP assays, disrupts the association of Mcl-1 with BH3-only proteins.
MI-238 is docked into Mcl-1 BH3 binding groove and proximal to the BH1 domain of Mcl-1.
MI-238 disrupts Bak/Mcl-1 interaction in a dose-dependent manner in vitro, directly binds to Mcl-1 and inhibits Mcl-1 anti-apoptotic function.
MI-238 treatment (20 uM) induced apoptosis in 50.1 ± 1.1% of parental H1299 cells, but not Mcl-1 deficient H1299 cells, caused caspase 3 cleavage, effectively induced apoptosis in AML cells.
MI-238 synergized with venetoclax to induce apoptosis in AML cells, and the combination of MI-238 and venetoclax potently inhibited the development of AML in murine model.

物理化学性质&存储条件

分子量	497.93
分子式	C29H20ClNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chloro-2-methylphenyl)-4-(naphthalen-2-yl)-2,4-dioxo-3-(3-oxo-1,3-dihydroisobenzofuran-1-yl)butanamide

参考文献

1. Tianming Zhao, et al. Mol Med. 2023 Jan 19;29(1):10.

MI-238 (MI 238)

生物&药学活性

物理化学性质&存储条件

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MI-238 (MI 238)

生物&药学活性

物理化学性质&存储条件

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