BM-1197 | Bcl-2/Bcl-xL inhibitor | Probechem Biochemicals

Chemical Structure : BM-1197

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BM-1197 (BM1197)

货号: PC-49799Not For Human Use, Lab Use Only.

BM-1197 (BM1197) is a potent and efficacious dual inhibitor of Bcl-2 and Bcl-xL with Ki of < 1 nM, >1,000-fold selectivity over Mcl-1.

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生物&药学活性

BM-1197 (BM1197) is a potent and efficacious dual inhibitor of Bcl-2 and Bcl-xL with Ki of < 1 nM, >1,000-fold selectivity over Mcl-1.
BM-1197 induces mechanism-based apoptosis in Mcl1-deficient mouse embryonic fibroblast (MEF) cells.
BM-1197 disrupts the association between BCL-XL and PUMA, induces BAX translocation and cytochrome c release and BAX/BAK-dependent apoptosis in MEF/MCL1 −/− cells.
BM-1197 exerts potent growth-inhibitory activity against small cell lung cancer (SCLC) cells in vitro (H146, IC50=3 nM).
BM-1197 IV daily at 10 mg/kg (5 days per week for 2 weeks) exhibited antitumor efficacy in SCID mice bearing H146 or H1963 cells.

物理化学性质&存储条件

分子量	1131.77
分子式	C53H59ClF4N6O7S4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[4-[3-[2-(4-Chlorophenyl)-5-methyl-1-(1-methylethyl)-4-(methylsulfonyl)-1H-pyrrol-3-yl]-5-fluorophenyl]-1-piperazinyl]phenyl]-4-[[(1R)-3-(4-hydroxy-1-piperidinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

参考文献

1. Longchuan Bai, et al. PLoS One. 2014 Jun 5;9(6):e99404.

BM-1197 (BM1197)

生物&药学活性

物理化学性质&存储条件

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BM-1197 (BM1197)

生物&药学活性

物理化学性质&存储条件

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