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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-CCT373567
CCT373567

Chemical Structure : CCT373567

CAS No.: 2378853-67-7

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CCT373567 (CCT 373567)

货号: PC-20626Not For Human Use, Lab Use Only.

CCT373567 is a potent, selective and cell-active BCL6 inhibitor with IC50 of 2.9 nM in TR-FRET assays, and 25.9 nM in NanoBRET cellular inhibition assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CCT373567 is a potent, selective and cell-active BCL6 inhibitor with IC50 of 2.9 nM in TR-FRET assays, and 25.9 nM in NanoBRET cellular inhibition assays.

物理化学性质&存储条件

分子量 547.00
分子式 C26H29ClF2N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C1N(C)C2=C(C=C(NC3=NC(N4C[C@@H](O)C[C@@H](C)C4)=NC=C3Cl)C=C2)C5=C1OCC(F)(F)[C@H](C6CC6)N5

参考文献

1. Alice C Harnden, et al. J Med Chem. 2023 Apr 7. doi: 10.1021/acs.jmedchem.3c00155.

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