BRD-810 | Mcl-1 inhibitor | Probechem Biochemicals

Chemical Structure : BRD-810

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BRD-810 (BRD810)

货号: PC-22977Not For Human Use, Lab Use Only.

BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.

规格	价格	库存	数量
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100 mg		Get quote

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生物&药学活性

BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.
BRD-810 shows no appreciable off-target binding versus a broad panel of enzymes, receptors and ion channels.
BRD-810-induced cell death indeed occurs through an on-target mechanism activating the intrinsic apoptotic pathway.
BRD-810 (25-50 mg/kg, intravenously injected once weekly) shows robust antitumor effects in monotherapy AMO-1 (multiple myeloma) tumor-bearing mice.

物理化学性质&存储条件

分子量	702.26
分子式	C40H45ClFN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-13-chloro-12-ethyl-1-(3-((6-fluoronaphthalen-1-yl)oxy)propyl)-11-methyl-9-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5,6,7,9,11-hexahydropyrazolo[4',3':9,10][1]oxa[6]azacycloundecino[8,7,6-hi]indole-2-carboxylic acid

参考文献

1. Rauh U, et al. Nat Cancer. 2024 Aug 23. doi: 10.1038/s43018-024-00814-0.

BRD-810 (BRD810)

生物&药学活性

物理化学性质&存储条件

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BRD-810 (BRD810)

生物&药学活性

物理化学性质&存储条件

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