BAM7 | Bax activator | Probechem Biochemicals

Chemical Structure : BAM7

CAS No.: 331244-89-4

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BAM7 (BAX activator BAM7)

货号: PC-22106Not For Human Use, Lab Use Only.

BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death.
BAM7 is selective for the BH3-binding site on BAX.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death.
BAM7 is selective for the BH3-binding site on BAX.
BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death.
BAM7 induces the biochemical and morphologic features of BAX-mediated apoptosis in Bak−/− MEFs.
BAM7 directly binds the BAX trigger site and initiates the characteristic structural changes that lead to functional BAX activation in vitro.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-ethoxyphenyl)hydrazone]

参考文献

1. Daniele S, et al. ACS Chem Neurosci. 2018 Jan 17;9(1):85-99.

2. Gavathiotis E, et al. Nat Chem Biol. 2012 Jul;8(7):639-45.

BAM7 (BAX activator BAM7)

生物&药学活性

物理化学性质&存储条件

参考文献

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BAM7 (BAX activator BAM7)

生物&药学活性

物理化学性质&存储条件

参考文献

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