M109S | Bax inhibitor | Probechem Biochemicals

Chemical Structure : M109S

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M109S (M 109S)

货号: PC-21258Not For Human Use, Lab Use Only.

M109S is a small molecule protecting cells from mitochondria-dependent apoptosis wtih EC50 of 23.4 nM in iBax cells, directly interacts with Bax (Kd=153 nM, MST assay) and inhibits Bax activation.

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生物&药学活性

M109S is a small molecule protecting cells from mitochondria-dependent apoptosis wtih EC50 of 23.4 nM in iBax cells, directly interacts with Bax (Kd=153 nM, MST assay) and inhibits Bax activation.
M109S inhibits the conformational change and mitochondrial translocation of Bax.
M109S inhibits ABT-737-induced apoptosis both in Bax-only and Bak-only mouse embryonic fibroblasts.
M109S also inhibits apoptosis induced by staurosporine, etoposide, and obatoclax.
M109S decreases maximal mitochondrial oxygen consumption rate and reactive oxygen species production, whereas it increased glycolysis.
M109 is an orally bioactive cell death inhibitor penetrating blood-brain/retina-barrier.
M109S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo.

物理化学性质&存储条件

分子量	375.43
分子式	C21H21N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)ethyl)-2,6-dimethylfuro[2,3-d]pyrimidin-4-amine

参考文献

1. Matsuyama M, et al. iScience. 2023 Sep 17;26(10):107916.

M109S (M 109S)

生物&药学活性

物理化学性质&存储条件

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M109S (M 109S)

生物&药学活性

物理化学性质&存储条件

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