Chemical Structure : BNIP3 antagonist peptide B-017
CAS No.:
BNIP3 antagonist peptide B-017
(TAT-WVELHFFN)
货号: PC-27103Not For Human Use, Lab Use Only.
B-017 is a mitochondrial protective peptide antagonist of BCL-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3), binds to both BNIP3 and BAX with KD of 700 nM and 303 nM respectively, preventing the direct activation of BAX and its insertion into mitochondrial outer membrane.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
B-017 is a mitochondrial protective peptide antagonist of BCL-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3), binds to both BNIP3 and BAX with KD of 700 nM and 303 nM respectively, preventing the direct activation of BAX and its insertion into mitochondrial outer membrane.
B-017 shows significant protection of the mitochondrial outer membrane (MOM), resulting in reduced levels of inserted BAX compared to mitochondria from wild-type MEFs and MCF-7 cells treated with staurosporine alone.
B-017 markedly inhibits the BAX insertion into the mitochondrial outer membrane (MOM), thereby preventing MOM permeabilisation.
B-017 effectively counteracts staurosporine-impaired cell viability, impedes the processes of apoptosis and necrosis induced by diverse stimuli in various mouse and human cell types.
B-017 has KD values of approximately 1.3 µM for BCL-2 and MCL-1.
B-017 induces protective biological responses in ischaemic C57BL/6 J wild-type mice, reduces tissue damage in the heart, brain, and liver.
物理化学性质&存储条件
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分子式
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外观性状
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Solid
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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参考文献
1. Hendgen-Cotta UB, et al. Nat Commun. 2026 Jun 17;17(1):5359.
