Navitoclax (ABT-263) | Bcl-2 inhibitor | Probechem Biochemicals

Chemical Structure : Navitoclax

CAS No.: 923564-51-6

加入收藏

Navitoclax (ABT-263, ABT263)

货号: PC-42277Not For Human Use, Lab Use Only.

Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.

规格	价格	库存
10 mg	￥780	In stock
50 mg	￥1280	In stock
100 mg	￥2180	In stock
250 mg	￥3780	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.
Navitoclax (ABT-263) binds more weakly to Mcl-1 and A1 (Ki>350 nM).
Navitoclax (ABT-263) disrupts Bcl-2/Bcl-xL interactions with pro-death proteins (e.g., Bim), induces apoptosis, shows cellular activity against a panel of human tumor cell lines (EC50<1 uM).
Navitoclax (ABT-263) induces complete tumor regressions in xenograft models of NSCLA and ALL.

物理化学性质&存储条件

分子量	974.6127
分子式	C47H55ClF3N5O6S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-

参考文献

1. Tse C, et al. Cancer Res. 2008 May 1;68(9):3421-8.

2. Shoemaker AR, et al. Clin Cancer Res. 2008 Jun 1;14(11):3268-77.

3. Ackler S, et al. Mol Cancer Ther. 2008 Oct;7(10):3265-74.

4. Shah OJ, et al. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12634-9.

Navitoclax (ABT-263, ABT263)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Navitoclax (ABT-263, ABT263)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.