MIM1 | Mcl-1 inhibitor | Probechem Biochemicals

Chemical Structure : MIM1

CAS No.: 509102-00-5

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MIM1 (MIM 1, MIM-1)

货号: PC-45041Not For Human Use, Lab Use Only.

MIM1 is a potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

MIM1 is a potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1.
MIM1 effectively competes with FITC-MCL-1 SAHBA and FITC-BID BH3 for MCL-1ΔNΔC binding with IC50 of 4.7 and 4.8 uM, respectively.
MIM1 shows no activity for Bcl-xL; induces caspase activation and leukemia cell death in the specific context of MCL-1 dependence.

物理化学性质&存储条件

分子量	347.4319
分子式	C17H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-

参考文献

1. Cohen NA, et al. Chem Biol. 2012 Sep 21;19(9):1175-86.

2. Habata S, et al. Int J Oncol. 2016 Jul;49(1):402-10.

MIM1 (MIM 1, MIM-1)

生物&药学活性

物理化学性质&存储条件

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MIM1 (MIM 1, MIM-1)

生物&药学活性

物理化学性质&存储条件

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