BH3I-1 (BHI1) | Bcl-2 inhibitor | Probechem Biochemicals

Chemical Structure : BH3I-1

CAS No.: 300817-68-9

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BH3I-1 (BHI1, BHI-1, BHI 1;BH 3I1)

货号: PC-42125Not For Human Use, Lab Use Only.

BH3I-1 (BHI1) is a small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

BH3I-1 (BHI1) is a small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.
BH3I-1 (BHI1) specifically blocks the BH3-domain-mediated heterodimerization between Bcl-2 family members in vitro and in vivo and induces apoptosis.
BH3I-1 (BHI1) also potently inhibits p53/hDM2 with Kd of 5.3 uM.

物理化学性质&存储条件

分子量	400.3105
分子式	C15H14BrNO3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 3.9 mg/mL
Chemical Name/SMILES	3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-

参考文献

1. Degterev A, et al. Nat Cell Biol. 2001 Feb;3(2):173-82.

2. Wang L, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.

3. Porter JR, et al. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.

BH3I-1 (BHI1, BHI-1, BHI 1;BH 3I1)

生物&药学活性

物理化学性质&存储条件

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BH3I-1 (BHI1, BHI-1, BHI 1;BH 3I1)

生物&药学活性

物理化学性质&存储条件

参考文献

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