Obatoclax (GX15-070) | Bcl-2 inhibitor | Probechem Biochemicals

Chemical Structure : Obatoclax

CAS No.: 803712-79-0

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Obatoclax (Obatoclax Mesylate, GX15-070)

货号: PC-42756Not For Human Use, Lab Use Only.

Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.
Obatoclax (GX15-070) potently interferes with the direct interaction between MCL-1 and BAK in intact mitochondrial outer membrane and inhibited the association between MCL-1 and BAK in intact cells;

物理化学性质&存储条件

分子量	413.49
分子式	C21H23N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 48.8 mg/mL
Chemical Name/SMILES	1H-Indole, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-, methanesulfonate (1:1)

参考文献

1. Zhai D, et al. Cell Death Differ. 2006 Aug;13(8):1419-21.

2. Nguyen M, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7.

3. Konopleva M, et al. Cancer Res. 2008 May 1;68(9):3413-20.

Obatoclax (Obatoclax Mesylate, GX15-070)

生物&药学活性

物理化学性质&存储条件

参考文献

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Obatoclax (Obatoclax Mesylate, GX15-070)

生物&药学活性

物理化学性质&存储条件

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