| Cat. No. |
Product Name |
Information |
| PC-61870 |
PF-04531083
Nav1.8 inhibitor
|
PF-04531083 (PF 4531083) is a potent and selective, orally available sodium channel Nav1.8 blocker for treatment of pain. |
| PC-61869 |
Funapide
NaV1.7/Nav1.8 inhibitor
|
Funapide (XEN402, TV-45070) is a potent and selective, orally available sodium channel Nav1.7 and Nav1.8 blocker for treatment of pain. |
| PC-61857 |
PF-05241328
NaV1.7 inhibitor
|
PF-05241328 (PF 5241328) is a potent and selective, orally active inhibitor of voltage-dependent sodium channel Nav1.7 with IC50 of 31 nM. |
| PC-61854 |
AZD-3161
NaV1.7 inhibitor
|
AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5. |
| PC-61853 |
PF-04856264
NaV1.7 inhibitor
|
PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5. |
| PC-61336 |
Lacosamide
Sodium channel inhibitor
|
Lacosamide (SPM 927) is an anticonvulsant compound that enhances the slow inactivation of voltage-gated sodium channels without affecting the fast inactivation of voltage-gated sodium channels. |
| PC-60629 |
AMG8379
NaV1.7 inhibitor
|
AMG 8379 (AMG-8379, AMG8379) is a potent and selective voltage-gated sodium channel Nav1.7 antaognist with IC50 of 8.5 nM. |
| PC-70213 |
Flecainide
Nav1.5 inhibitor, RyR2 inhibitor
|
Flecainide (R818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
| PC-60194 |
AnCoA4
Orai1 channel inhibitor
|
AnCoA4 (AnCoA-4, Jamaicin) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
| PC-60005 |
A-317567
|
A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM. |
| PC-47508 |
Benzocaine
Sodium channel inhibitor
|
Benzocaine is a local anesthetic, inhibits voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential. |
| PC-45927 |
Proparacaine hydrochloride
Sodium channel inhibitor
|
Proparacaine hydrochloride (Proxymetacaine hydrochloride) is an irreversible local anesthetic, inhibits pain sensations that is believed to act as an antagonist on voltage-gated sodium channels. |
