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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-GNE-0439
GNE-0439

Chemical Structure : GNE-0439

CAS No.: 1241902-40-8

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GNE-0439 (GNE0439)

货号: PC-62325Not For Human Use, Lab Use Only.

GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM).

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2880 In stock
25 mg ￥4280 In stock
50 mg ￥7280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM).
GNE-0439 also inhibits mutant N1742K channels with IC50 of 0.37 uM in membrane potential assays, but not mutation of R1608A (IC50>50 uM).
GNE-0439 is unique compared with known selective VSD4 binders such as the arylsulfonamides (GX-936 and PF-05089771).

物理化学性质&存储条件

分子量 345.483
分子式 C21H31NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(4-propylcyclohexyl)benzoyl)-L-valine

参考文献

1. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.

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