| Cat. No. |
Product Name |
Information |
| PC-23761 |
Phenamil methanesulfonate
ENaC inhibitor
|
Phenamil methanesulfonate is a potent, reversible epithelial sodium channel (ENaC) blocker with IC50 of 400 nM, is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with IC50 of 140 nM in Ca2+ uptake assay. |
| PC-23672 |
Amiloride
ENaC inhibitor
|
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC and urokinase-type plasminogen activator receptor (uTPA), also is a blocker of polycystin-2 (PC2, TRPP2) channel. |
| PC-23587 |
Nav1.8 inhibitor 42
Nav1.8 inhibitor
|
Nav1.8 inhibitor 42 is a potent, selective Nav1.8 inhibitor with IC50 of 35 nM (human Nav1.8), shows weak actiivty against mouse Nav1.8 (IC50=3040 nM). |
| PC-23533 |
NaV1.7 inhibitor 31
Nav1.7 inhibitor
|
NaV1.7 inhibitor 31 is a potent and selective inhibitor of Nav1.7 with Ki/IC50 of 4.9 nM/13 nM (hNav1.7), >400-fold selective over hNav1.5. |
| PC-23462 |
ETD001
ENaC inhibitor
|
ETD001 is a potent, selective epithelial sodium channel (ENaC) inhibitor with IC50 of 57 nM. |
| PC-22308 |
QLS-81
Nav1.7 inhibitor
|
QLS-81 is a potent, selective Nav1.7 channel inhibitor with IC50 of 3.5 uM for inhibition of Nav1.7 current in whole-cell patch-clamp recording assay. |
| PC-21839 |
S3969
ENaC activator
|
S3969 is a small molecule activator of the human epithelial sodium channel (ENaC) with EC50 of 1.2 uM in ENaC-expressing oocytes. |
| PC-21711 |
UTX-143
NHE5 inhibitor
|
UTX-143 is a potent, selective sodium-hydrogen exchange subtype 5 (NHE5) inhibitor with IC50 of 3.11 uM, 80-fold selective over NHE1. |
| PC-21230 |
Aneratrigine
Sodium Channel inhibitor
|
Aneratrigine is a sodium channel protein type 9 subunit alpha blocker. |
| PC-20850 |
DS43260857
NaV1.7 inhibitor
|
DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively. |
